Fig. 1. Crystal Structure of Wild Type BRAF- MEK
Figure 2: Dependence of RMSD(root-mean-square deviation) on the configuration number
The fig.2 shows a rapidly oscillating character, which indicates the impossibility of finding a local minimum: optimization completed because at the initial point, the objective function is nondecreasing in feasible directions. As follows from the fig.1 the local minimum no found.
Dependence of RMSD(root-mean-square deviation) on the configuration number.
G-573 is an allosteric inhibitor of MEK that is both potent and selective.
error computational SVD