Dose–response curves of CS292 from an ELISA-based BRAF kinase inhibition assay
CS292 Concentrarion ( M x 10____ )
The most potent BRAF inhibitor, CS292, was also shown to have an 2-fold selectivity for BRAFV600E (IC50 = 0.21 мM) over the wild-type enzyme
Agreement between calculated and experimental data
Fig. Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
Fig. Graph for determining the normality of the distribution for the subsequent determination of the change in information entropy.
error computational SVD
Figure 3: Dependence of RMSD(root-mean-square deviation) on the configuration number
The fig.1 shows a rapidly oscillating character, which indicates the impossibility of finding a local minimum: optimization completed because at the initial point, the objective function is nondecreasing in feasible directions. As follows from the fig.1 the local minimum no found.
Dependence of RMSD(root-mean-square deviation) on the configuration number.